Cervical dystonia: clinical and therapeutic features in 85 patients

Arquivos de Neuro-Psiquiatria

Carlos Henrique F. Camargo¹  Hélio A.g. Teive¹  Nilson Becker¹  Maria Helena Herdoíza Baran¹  Rosana Hermínia Scola¹  Lineu César Werneck¹ 

[1] ,Federal University of Paraná Hospital de Clínicas Department of Clinical MedicineCuritiba PR ,Brazil

关键词: dystonia;    cervical dystonia;    botulinum toxin;    dysphagia;    distonia;    distonia cervical;    toxina botulínica;    disfagia;   

DOI  :  10.1590/S0004-282X2008000100005

来源: SciELO

【 摘 要 】

We studied patients with cervical dystonia (CD) to determine clinical features and response to botulinum toxin A (BoNT/A). Patients were submitted to clinical, laboratory and neuroimaging evaluation. BoNT/A was injected locally in 81 patients using electromyographic guidance. Four patients who had had previous treatment were considered to be in remission. The average ages at onset of focal dystonia and segmental dystonia were greater than for generalized dystonia (p<0.0003). The severity of the abnormal head-neck movements were more severe among the patients with generalized dystonia (p<0.001). Pain in the cervical area was noted in 59 patients. It was not possible to determine the etiology of the disease in 62.3% of patients. Tardive dystonia was the most common secondary etiology. A major improvement in the motor symptoms of CD and pain was observed in patients following treatment with BoNT/A. The tardive dystonia subgroup did not respond to the treatment. Dysphagia was observed in 2.35% of the patients.

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