First, do no harm: the risks of overtreating children with epilepsy

Arquivos de Neuro-Psiquiatria

Eunice Chuang¹  Marilisa M. Guerreiro¹  Sara Y. Tsuchie¹  Angelica Santucci¹  Carlos A. M. Guerreiro¹  Maria Augusta Montenegro¹ 

[1] ,State University of Campinas Department of NeurologySP ,Brazil

关键词: epilepsy;    children;    antiepileptic drug;    overtreatment;    epilepsia;    infância;    droga antiepiléptica;    tratamento excessivo;   

DOI  :  10.1590/S0004-282X2007000100002

来源: SciELO

【 摘 要 】

BACKGROUND: Although overtreatment with antiepileptic drugs contributes to the morbidity associated with epilepsy, many children still are overtreated. OBJECTIVE: To evaluate if the withdrawal of at least one antiepileptic drug (AED) in children with refractory epilepsy using polytherapy enable a better seizure control. METHOD: This was a prospective study. Children with refractory epilepsy using at least two AEDs were included. Once the patient, or guardian, agreed to participate in the study, one or more AED were slowly tapered off. The remaining AEDs dosages could be adjusted as needed, but a new AED could not be introduced. RESULTS: Fifteen patients were evaluated, three girls; ages ranging from 3 to 18 (mean=8.7 years). After at least one AED withdrawal, two (13.5%) patients became seizure free, seizures improved >50% in 5 (33.5%) patients, did not change in 5 (33.5%), and seizure frequency became worse in 3 (20%). Adverse events improved in 12 patients (80%). CONCLUSION: The withdrawal of at least one AED is a valuable option in the treatment of selected children with refractory epilepsy.

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