Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms

Arquivos de Neuro-Psiquiatria

Vanessa Cavalcante Da Silva²  Flávio José Da Costa Ramos²  Elizabete Malaquias Freitas²  Paulo Roberto De Brito-marques¹  Márcia Nery De Holanda Cavalcanti¹  Vânia D’almeida¹  José Eulálio Cabral-filho¹  Maria Tereza Cartaxo Muniz² 

[1],Universidade de Pernambuco Instituto de Ciências Biológicas Recife PE ,Brazil

关键词: homocysteine;    MTHFR;    Alzheimer’s disease;    homocisteína;    MTHFR;    doença de Alzheimer;   

DOI  :  10.1590/S0004-282X2006000600010

来源: SciELO

【 摘 要 】

OBJECTIVE: To investigate the association between total plasma homocysteine concentration, C677T and A1298C polymorphisms in MTHFR gene and Alzheimer's disease (AD) development. METHOD: Forty-three patients with probable (63%) and possible (37%) AD and 50 non-demented controls were evaluated. Groups did not differ as to gender, age, scholar years, diabetes, alcohol and coffee intake and physical activity. Total plasma homocysteine (Hcy) levels were determined by HPLC and genotyping for MTHFR by PCR/RFLP. Mann-Whitney "U" test was used to compare quantitative variable, Fisher-Freeman-Halton test to compare genotypes and allele proportions and Chi-square test to other qualitative variables. RESULTS: AD patients presented higher total plasma Hcy levels than controls and the difference was statistically significant. No differences in the C677T and A1298C MTHFR polymorphisms distributions were found between patients and controls. Plasma homocysteine concentration did not change with MTHFR genotypes. CONCLUSION: Our data confirms the association between increased plasma Hcy concentration and AD and suggests that neither C677T nor A1298C MTHFR polymorphisms contributed to genetic susceptibility for AD in elderly individuals in the Northeast of Brazil.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License