Effect of glycemic state in rats submitted to status epilepticus during development

Arquivos de Neuro-Psiquiatria

Joselita F.c. Santiago²  Fatima F. Carvalho¹  Sandra R. Perosa¹  Marcelo R. Siliano¹  José Walber M.c. Cruz¹  Maria José S. Fernandes¹  Esper A. Cavalheiro¹  Débora Amado¹  Maria Da Graça Naffah-mazzacoratti¹ 

[1] ,Universidade Federal de São Paulo Departamento de Neurologia e Neurocirurgia São Paulo SP ,Brazil

关键词: status epilepticus;    pilocarpine;    glycemia;    hippocampus;    glucose transporter 3;    status epilepticus;    pilocarpina;    glicemia;    hipocampo;    transportador de glicose 3;   

DOI  :  10.1590/S0004-282X2006000200012

来源: SciELO

【 摘 要 】

The effect of glycemic state on status epilepticus (SE) development was studied in animals of different ages, submitted to pilocarpine model of epilepsy. Groups: I- Rats with 9-day-old (P9): IA. Submitted to 1SE; IB. Saline-treated; IC. Induced- hyperglycemia; ID. Induced- hyperglycemia+SE; II- Rats submitted to three consecutive episodes of SE at P7, P8 and P9; III- Rats submitted to 1SE at P17; IV- Rats submitted to 1SE at P21. Hippocampal cell death and the expression of glucose transporter GLUT3 were analyzed in group I. The results demonstrated normoglycemia in the groups IA, IB and II, hypoglycemia in group III and hyperglycemia in group IV, showing that the glycemia during SE is age dependent. Induced hyperglycemia during SE in P9 protected the hippocampal neurons from death and both groups IC and ID presented increased GLUT3 expression, showing high glucose consumption by the hippocampus.

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