Leptomeningeal dissemination of pilocytic astrocytoma at diagnosis in childhood: two cases report

Arquivos de Neuro-Psiquiatria

Eberval Gadelha Figueiredo¹  Hamilton Matushita¹  André Guelman G. Machado¹  José Píndaro P. Plese¹  Sérgio Rosemberg¹  Raul Marino Jr¹ 

[1],São Paulo University Clinics Hospital School Of MedicineSão Paulo SP ,Brazil

关键词: pilocytic astrocytoma;    leptomeningeal dissemination;    multicentric disease;    cerebrospinal fluid;    metastasis;    radiation therapy;    chemotherapy;    hydrocephalus;    astrocitoma pilocítico;    disseminação leptomeníngea;    doença multicêntrica;    líquor;    metástases;    quimioterapia;    radioterapia;   

DOI  :  10.1590/S0004-282X2003000500025

来源: SciELO

【 摘 要 】

Pilocytic astrocytoma (PA) is a benign tumor that rarely spread along the neuraxis. At the moment there are no more than five cases of leptomeningeal dissemination (LD) from PA at diagnosis described in the literature. Different patterns of presentation or recurrence may be noted: local recurrence, malignant transformation, multicentric disease or metastatic disease. LD and multicentric disease can be distinct pathological entities. We report two cases and analyse literature, emphasizing leptomeningeal spread at presentation. Hydrocephalus, biopsy and parcial ressection are likely to be favorable factors to the occurrence of LD. Otherwise, LD may be part of natural history of PA, as evidenced by its ocurrence in non-treated cases.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License