Medulloblastoma: evaluation of proliferative index by monoclonal antibody Mib-1, its prognostic correlation and therapeutic implications

Arquivos de Neuro-Psiquiatria

Antonio Fernandes Ferrari¹  Maria Betânia Mahler Araújo²  Paulo Henrique Aguiar¹  José Pindaro Pereira Plese¹ 

[1] ,AC Camargo Hospital of São Paulo Neuropathological Institute São Paulo SP ,Brazil

关键词: medulloblastoma;    labelling index (LI);    mib-1;    prognostic factors;    meduloblastoma;    índice proliferativo (IP);    Mib1;    fatores prognósticos;   

DOI  :  10.1590/S0004-282X2003000400004

来源: SciELO

【 摘 要 】

In the past few years, the monoclonal antibody MIB-1 has been used by researchers in order to retrospectively study paraffin imbibed tumor fragments. The medulloblastoma is the most common malignant central nervous system tumor in childhood. The objectives were: determination of the mean Mib-1 LI value from these patients, as well as the prognostic value of the method.This retrospective study represents an analysis of the cellular proliferation index of posterior fossa medulloblastomas collected from 22 patients at A.C. Camargo Hospital, from January 1990 to December 1999. The histopathological diagnosis was confirmed by H&E and proliferative index (LI) was achived with Mib-1 which detects proliferating cells during G1, G2, S and M phases.The results demostrated that the mean Mib-1 was 30,1%, and ranged from 5,2% to 62,0%.In conclusion, this method has prognostic value, has to be used as routine for patients harboring medulloblastomas and the ones who have PI greater than the mean value found in this study, should be treated aggressively.

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