Glioblastoma multiforme of the pineal region: case report

Arquivos de Neuro-Psiquiatria

Emerson Leandro Gasparetto²  Danny Warszawiak¹  Guilherme Pradi Adam²  Luiz Fernando Bleggi-torres¹  Arnolfo De Carvalho Neto¹ 

[1] ,Universidade Federal do Parana Hospital de Clinicas

关键词: brain tumor;    pineal gland;    glioblastoma multiforme;    tumor encefálico;    glândula pineal;    glioblastoma multiforme;   

DOI  :  10.1590/S0004-282X2003000300027

来源: SciELO

【 摘 要 】

PURPOSE: pineal region tumors are uncommon, and comprise more frequently three categories: germ cell, parenchymal cell and glial tumors. Most pineal gliomas are low-grade astrocytomas. Glioblastoma multiforme, the most aggressive and common brain tumor, is extremely rare at this location with only few cases reported. CASE DESCRIPTION: a 29-year-old woman with a two month history of headache, nuchal pain, fever, nausea and seizures and physical examination showing nuchal rigidity, generalized hypotony, hypotrophy and hyper-reflexia, Babinski sign and left VI cranial par palsy. CT scan examination revealed a ill-defined hypodense lesion at the pineal region with heterogeneous contrast enhancement. MRI showed a lesion at the pineal region infiltrating the right thalamic region. The patient underwent a right craniotomy with partial resection of the mass. The histological examination of paraffin-embedded material defined the diagnosis of glioblastoma multiforme. Post-operative radiotherapy was indicated but the patient refused the treatment and died two months afterwards. CONCLUSION: in spite of its rarity at this location, glioblastoma multiforme should be considered in the differential diagnosis of aggressive lesions at the pineal region.

【 授权许可】

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