Malignant paraganglioma with vertebral metastasis: case report

Arquivos de Neuro-Psiquiatria

Bruno Lázaro¹  Mônica Klemz²  Marlo Steiner Flores¹  José Alberto Landeiro¹ 

[1] ,Brazilian Air Force HospitalRio de Janeiro RJ ,Brazil

关键词: paraganglioma;    vertebral metastasis;    spinal tumor;    paraganglioma maligno;    metástase vertebral;    tumor vertebral;   

DOI  :  10.1590/S0004-282X2003000300026

来源: SciELO

【 摘 要 】

A paraganglioma is a rare tumor, composed of chromaffin cells, groups of cells associated to the autonomous system. When the tumor occurs in the adrenal gland, it is called pheochromocitoma. The malignant paraganglioma is a very rare presentation; it is diagnosed by local recurrence after total resection of the primary mass, or findings of distant metastases. We present a case report of a 29-year-old woman with cervico-brachial pain. In 1995 she underwent a carotid body tumor resection. Magnetic resonance imaging (MRI), plain X-rays and computerized tomography scan revealed multiple lesions in C5, T5 and T12. She underwent a surgical procedure to correct the cervical lesion. The histological and immunohistochemical assays revealed a malignant paraganglioma. She received adjuvant radiotherapy, showing clinical improvement after treatment, presenting no symptoms after one year. The therapeutic approach is based on the total resection of the tumor. The treatment of distant metastases can be made with adjuvant measures such as conventional radiotherapy, I¹³¹-MIBG, or chemotherapy, especially in malignant pheochromocitomas.

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