Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 children

Arquivos de Neuro-Psiquiatria

Isac Bruck²  Tony Tannous Tahan¹  Cristina Rodrigues Da Cruz¹  Luzilma Terezinha Flenik Martins¹  Sérgio Antonio Antoniuk²  Marcelo Rodrigues¹  Sílvia Mara De Souza¹  Laís Regina De Bruyn¹ 

[1],Federal University of Parana Clinical Hospital Pediatric DepartmentCuritiba PR ,Brazil

关键词: human immunodeficiency virus (HIV);    neurodevelopment delay;    neurological screening test;    vírus da imunodeficiência humana (HIV);    atraso no neurodesenvolvimento;    testes neurológicos de screening;   

DOI  :  10.1590/S0004-282X2001000500007

来源: SciELO

【 摘 要 】

The aim of the study was to detect neurological abnormalities in human immunodeficiency virus (HIV) infected children. This was achieved by a prospective evaluation, from November/1995 to April/2000, of 43 HIV infected children (group I) and 40 HIV seroreverters children (group II) through neurological exam and neurodevelopmental tests: Denver Developmental Screening Test (DDST) and Clinical Adaptive Test / Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS). A control group (III), of 67 children, were evaluated by CAT/CLAMS. Hyperactivity, irritability and hypotonia were the findings on neurological examination, without statistical differences between group I and II. On CAT/CLAMS, the group I developmental quotient (DQ) was significantly lower than the other groups. The same occurred in DDST, with group I presenting significantly more failures than group II. Nineteen HIV children of group I had brain computed tomographic scan, with abnormalities in three of them (basal ganglia calcification, white matter hypodensity and asymmetry of lateral ventricles). We conclude that in HIV infected children a neurodevelopment delay occur early in the disease, and it can be detected by screening tests.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License