IgG2 immunodeficiency: association to pediatric patients with bacterial meningoencephalitis

Arquivos de Neuro-Psiquiatria

Xiomara Escobar-pÉrez¹  Alberto J. Dorta-contreras¹  Maria Teresa InteriÁn-morales¹  Elena Noris-garcÍa¹  Maritza FerrÁ-valdÉs¹ 

[1] ,Hospital Psiquiátrico San Miguel del Padrón Laboratorio de Inmunología Ciudad Habana,Cuba

关键词: IgG subclass;    IgG2 deficiency;    albumin;    cerebrospinal fluid;    serum;    meningitis;    IgG subclase;    IgG2 deficiencia;    albúmina;    líquido cefalorraquídeo;    suero;    meningoencefalites;   

DOI  :  10.1590/S0004-282X2000000100021

来源: SciELO

【 摘 要 】

An IgG subclass deficiency is often associated with bacterial infections. We studied four pediatric patients suffering from meningoencephalitis, two of them due to Streptococcus pneumoniae and two due to Haemophilus influenzae type b. Simultaneous diagnostic serum and cerebrospinal fluid samples were taken during income. The four subclasses of IgG and albumin were quantified in both biologic fluids by radial immunodiffusion. Very low levels of seric IgG2 with non detectable cerebrospinal fluid IgG2 were found in the patients. No intrathecal IgG subclass synthesis was found in two patients. One patient with S. pneumoniae had IgG3 intrathecal synthesis. Intrathecal IgG1, IgG3 and IgG4 synthesis was found in one patient suffering from H. influenzae according with reibergrams. Substitutive therapy with intravenous gammaglobulin was given to the patients as part of the treatment.

【 授权许可】

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