Morphological and quantitative analysis of the neurons of the myenteric plexus of the cecum of streptozotocin-induced diabetic rats

Arquivos de Neuro-Psiquiatria

Jacqueline Nelisis Zanoni²  Marcilio Hubner De Miranda-neto²  Roberto Barbosa Bazotte¹  Romeu Rodrigues De Souza¹ 

[1] ,State University of Maringá Department of Morphophysiological Sciece

关键词: myenteric neurons;    diabetes mellitus;    myenteric plexus;    neurônios mientéricos;    diabetes mellitus;    plexo mientérico;   

DOI  :  10.1590/S0004-282X1997000500004

来源: SciELO

【 摘 要 】

The purpose of this work was to study the neurons of the myenteric plexus of the cecum of rats with chronic streptozotocin-induced diabetes. We used four experimental groups of animals. In groups D2 and D8 animals were killed two and eight months, respectively, after diabetes induction and groups C2 and C8 were used as controls. We carried out whole-mount preparations stanied with Giemsa and NADH-diaphorase. We verified that the diabetes did not alter the shape and disposition of the myenteric ganglia; it provoked decrease on the neuronal density and increase on the incidence of weakly basophilic neurons. The effects of streptozotocin caused dilatation of the cecum still evidenced two months after induction, but no more observed on the eight months after induction. The smaller incidence of neurons in group D8 relative to group C8 was due to the early loss related to the drug toxicity and later to the aging in diabetic condition.

【 授权许可】

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