Severe forms of neurocysticercosis: treatment with albendazole

Arquivos de Neuro-Psiquiatria

Svetlana Agapejev¹  Maria Dorvalina Da Silva¹  Anete K. Ueda¹ 

[1] ,State University of São Paulo Botucatu School of Medicine Department of Neurology and Psychiatry and Department of Pathology

关键词: cysticercosis;    neurocysticercosis;    severe forms;    treatment;    albendazole;    dextrochloropheniramine;    ketoprofen;    cisticercose;    neurocisticercose;    formas graves;    tratamento;    albendazol;    dextroclorofeniramina;    cetoprofeno;   

DOI  :  10.1590/S0004-282X1996000100014

来源: SciELO

【 摘 要 】

Study of 22 patients with the severe form of neurocysticercosis treated with albendazole (ABZ) administered in 6 different schedules ranging from 15 to 30 mg/kg/day for 21 to 60 days. Dextrochloropheniramine and ketoprofen were the adjuvant drugs. Multiple symptoms were observed in 90.9% of patients. Intracranial hypertension was manifested in 90.9%. Hydrocephaly occurred in 86.4%. Evolution was satisfactory in 10 patients, 8 died and 4 had sequelae. Tomographic studies showed the appearance of an isolated IVth ventricle in 9 patients, after ventriculoperitoneal shunt, before ABZ treatment in 3 of them, during in 5 and after treatment in one. Median clinical follow-up duration was 10 months for the patients who died and 3-4 years for survivors. In 3 patients there was an increase in cyst size during the administration of the 15 mg/kg/day ABZ dose, which was not observed in any patient when the 30 mg/kg/day dose was used.

【 授权许可】

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