Familial glioblastoma

Arquivos de Neuro-Psiquiatria

Walter O. Arruda¹  Rogério S. Clemente¹  Ricardo Ramina¹  Ari A. Pedrozo¹  Rui F. Pilotto²  Walter Pinto Jr.¹  Luiz F. Bleggi-torres¹ 

[1] ,Universidade Federal do Paraná Unidade de Genética Médica

关键词: glioblastoma;    chromosomes;    cytogenetics;    oncogenesis;    glioblastoma;    cromossomos;    citogenética;    oncogênese;   

DOI  :  10.1590/S0004-282X1995000200025

来源: SciELO

【 摘 要 】

The authors describe a family with three members affected by glioblastoma. The proband patient, a 7 year-old girl, developed a rare complication, a pulmonary metastasis. Chromosomal analysis of her peripheral blood lymphocytes showed a normal karyotype (46, XX), without structural abnormalities. Cytogenetic study of the tumor cells disclosed several abnormalities: 46, XX, 7q - / 46, XX, -2, 4p-, 7p-, +15/ 46, XX. Some aspects about genetics of glial neoplasms are discussed.

【 授权许可】

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