Carbamazepine kinetics in cardiac patients before and during amiodarone

Arquivos de Neuro-Psiquiatria

Silmara A.o. Leite²  Paulo J.m. Leite²  Gilberto A. Rocha¹  Philip A. Routledge¹  Paulo Rogério M. Bittencourt² 

[1] ,Hospital Nossa Senhora das Graças Serviço de Neurologia Curitiba,Brasil

关键词: amiodarone;    carbamazepine;    epilepsy;    antiepileptic drags;    arrythmia;    amiodarona;    carbamazepina;    drogas antiepilépticas;    arritmias;   

DOI  :  10.1590/S0004-282X1994000200010

来源: SciELO

【 摘 要 】

Carbamazepine and amiodarone may often be used together, especially in countries where cardiomyopathies are common. In this study single doses of carbamazepine (400 mg) were given to patients with cardiac disease before and after one month of therapy with amiodarone, 400 mg daily. The kinetic profile of carbamazepine, its free fraction, and serum amiodarone, were measured at the two occasions. There was no statistically significant change in carbamazepine kinetics or free fraction, before and after the introduction of amiodarone. The concentrations of amidarone after one month of therapy were low. It is sugested that the possible interaction in the hepatic metabolism was not demonstrated because amiodarone concentrations were not enough to inhibit carbamazepine metabolism.

【 授权许可】

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