HTLV-1 and myelopathy in Salvador (Northeastern Brazil): a case control study

Arquivos de Neuro-Psiquiatria

Ines Lessa²  Dilcineia Moraes¹  Luciana Moura¹  Aílton Melo¹ 

[1] ,Federal University of Bahia Department of Preventive Medicine Salvador

关键词: HTDV-1;    retrovirus;    analytical studies;    tropical spastic paraparesis;    Brazil;    HTLV-1;    retrovirus;    estudo analítico;    paraparesia espástica tropical;    Brasil;   

DOI  :  10.1590/S0004-282X1993000400004

来源: SciELO

【 摘 要 】

The principal aim of the study was to determine the degree of association between cerebrospinal fluid (CSF) that is positive for HTLV-1 and myelopathy in Salvador, Brazil. From the same hospital, twenty-eight cases of myelopathy and twenty-eight cases showing no neurological disorder were studied using blind selection matched 1:1 by age and sex. The twenty-eight pairs underwent HTLV-1 serology tests. In those with a positive result, anti-HTLV-1 antibodies were investigated in the CSF. The ELISA method was used, complemented by the Western-blot test. Myelopathy was considered associated with HTLV-1 only when the CSF was positive indicating neurotropism of the virus. The mean age of the cases was 44.6 ± 15.6 years and the control group was 43.5 ± 16.0 (p>0.05). An OR of 9.0 was detected with a reability interval (95%) of 1.652-48.866 and chi-square significant at the 0.02 level. Despite a strong degree of association and considering the low level of precision, there is a need for analytical studies with larger samples which besides improving the precision will allow for greater control of the confounding variables.

【 授权许可】

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