A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats

Arquivos de Neuro-Psiquiatria

João S. Pereira¹  Paulo H. P. Bertolucci¹  Henrique B. Ferraz¹  Luiz A. F. De Andrade¹ 

[1] ,Escola Paulista de Medicina Department of Neurology and Neurosurgery Sector for Investigation of Extrapyradimal Diseases

关键词: tardive dyskinesia;    calcium channel blockers drugs;    neuroleptics;    discinesia tardia;    drogas bloqueadoras de canais de cálcio;    neuro-lépticos;   

DOI  :  10.1590/S0004-282X1992000300001

来源: SciELO

【 摘 要 】

Tardive dyskinesia (TD), a serious complications of neuroleptic chronic use, has no effective therapy yet. We performed an experiment to study the action on TD, of the calcium channel blockers (CCB) drugs, verapamil and flunarizine. We obtained the TD model in rats, administering haloperidol for a 21-day period. After this, the stereotyped movement induced by apomorphyne was rated. The CCB drugs were administered in acute (in the 28th. day) and chronic (for 8 days, after the 25th day) experiments. Acutely, verapamil increased the stereotyped behaviour, and promoted a reduction of it in the chronic experiment. The results suggest that CCB drugs should be tested in clinical trials of TD.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License