COMPARISON OF FECAL ELASTASE 1 FOR EXOCRINE PANCREATIC INSUFFICIENCY EVALUATION BETWEEN EX-ALCOHOLICS AND CHRONIC PANCREATITIS PATIENTS

Arquivos de Gastroenterologia

Rejane Mattar¹  Gustavo André Silva Lima¹  Marianges Zadrozny Gouvêa Da Costa¹  Joyce M Kinoshita Silva-etto¹  Dulce Guarita¹  Flair José Carrilho¹ 

关键词: Pancreatic elastase;    Chronic pancreatitis;    Alcoholics;    Exocrine pancreatic insufficiency;    Elastase pancreática;    Pancreatite crônica;    Alcoólicos;    Insuficiência pancreática exócrina;   

DOI  :  10.1590/S0004-28032014000400006

来源: SciELO

【 摘 要 】

Context Fecal elastase is a noninvasive test for pancreatic insufficiency diagnosis. ObjectivesEvaluate the usefulness of fecal elastase 1 for the indication of exocrine pancreatic insufficiency among former alcohol addicts and patients with chronic pancreatitis. Methods Forty-three patients with chronic pancreatitis and thirty-three asymptomatic former alcohol addicts entered the study. The levels of fecal elastase 1 were measured using a commercial kit. Pancreatic imaging findings were used to categorize the groups.Results The levels of fecal elastase 1 were significantly lower in the patients than in the former alcohol addicts and in the group with tissue calcifications, duct alterations, or atrophy. With a cutoff level of 100 μg/g, the sensitivity of fecal elastase 1 in chronic pancreatitis was 46.51% and its specificity was 87.88% with a positive predictive value of 83.33% and a negative predictive value of 55.77%. When patients were stratified according to the severity of their pancreatitis, the sensitivity was 6.25% for mild pancreatitis and 70.37% for marked pancreatitis. Conclusion Low level of fecal elastase 1 was associated with marked rather than mild chronic pancreatitis; however, it may be useful to indicate pancreatic exocrine insufficiency in asymptomatic former alcohol addicts.

【 授权许可】

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