Predictive factors of early graft loss in living donor liver transplantation

Arquivos de Gastroenterologia

Rogério Camargo Pinheiro Alves²  Eduardo Antunes Da Fonseca¹  Carla Adriana Loureiro De Mattos¹  Sofia Abdalla¹  José Eduardo Gonçalves¹  Jaques Waisberg¹ 

[1] ,Hospital do Servidor Público Estadual Department of Gastroenterology

关键词: Liver transplantation;    Living donor;    Prognosis;    Primary graft dysfunction;    Graft survival;    Transplante de fígado;    Doadores vivos;    Prognóstico;    Disfunção primária do enxerto;    Sobrevivência do enxerto;   

DOI  :  10.1590/S0004-28032012000200011

来源: SciELO

【 摘 要 】

CONTEXT: Living donor liver transplantation has become an alternative to reduce the lack of organ donation. OBJECTIVE: To identify factors predictive of early graft loss in the first 3 months after living donor liver transplantation. METHODS: Seventy-eight adults submitted to living donor liver transplantation were divided into group I with 62 (79.5%) patients with graft survival longer than 3 months, and group II with 16 (20.5%) patients who died and/or showed graft failure within 3 months after liver transplantation. The variables analyzed were gender, age, etiology of liver disease, Child-Pugh classification, model of end-stage liver disease (MELD score), pretransplantation serum sodium level, and graft weight-to-recipient body weight (GRBW) ratio. The GRBW ratio was categorized into < 0.8 and MELD score into >18. The chi-square test, Student t-test and uni- and multivariate analysis were used for the evaluation of risk factors for early graft loss. RESULTS: MELD score <18 (P<0.001) and serum sodium level > 135 mEq/L (P = 0.03) were higher in group II than in group I. In the multivariate analysis MELD scores > 18 (P<0.001) and GRBW ratios < 0.8 (P<0.04) were significant. CONCLUSIONS: MELD scores >18 and GRBW < 0.8 ratios are associated with higher probability of graft failure after living donor liver transplantation.

【 授权许可】

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