Locally advanced colorectal cancer: results of surgical treatment and prognostic factors

Arquivos de Gastroenterologia

Fábio Guilherme Campos²  Maria Célia Calijuri-hamra¹  Antonio Rocco Imperiale²  Desidério Roberto Kiss²  Sergio Carlos Nahas²  Ivan Cecconello² 

[1] ,Universidade de São Paulo Faculdade de Medicina Hospital das Clínicas

关键词: Colorectal neoplasms;    surgery;    Neoplasias colorretais;    cirurgia;   

DOI  :  10.1590/S0004-28032011000400010

来源: SciELO

【 摘 要 】

OBJECTIVES: To evaluate the incidence surgical results and prognostic factors of locally advanced colorectal cancer. METHODS: Cohort study including 679 colorectal cancer patients treated from 1997 to 2007. Clinical, surgical and histological data were analyzed. RESULTS: Ninety patients (females 61%; median age 59 years) were treated for locally advanced carcinomas (13.2%), either in the colon (66%) or rectum (34%). Extended resections most commonly involved the small bowel (19.8%), bladder (16.4%), uterus (12.9%) and ovaries (11.2%). Postoperative morbidity and mortality occurred in 23 (25.6%) and 3 (3.3%) patients, respectively. Survival and recurrence analysis among 76 R0 (84.4%) procedures revealed a 60% 5-year survival and 34% local recurrence rates. Survival curves demonstrated reduced rates for rectal location (45% vs 65%), tumor depth (50% for T4 vs 75% for T3), vascular/ lymphatic/perineural invasion (35% vs 80%) and lymph node metastasis (35% vs 80%). CONCLUSIONS: Locally advanced carcinomas were found in 13.2% of patients. Survival rates were negatively affected by rectal location and adverse histological features. Number of involved organs and neoplastic adhesions did not influenced chances of survival. A radical R0 extended resection was achieved in a high proportion of cases, resulting in a 60% cancer-free survival under acceptable operative risks.

【 授权许可】

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