Antiangiogenic drugs and advanced proliferative diabetic retinopathy

Arquivos Brasileiros de Oftalmologia

Jefferson Augusto Santana Ribeiro¹  André Messias¹  Rodrigo Jorge¹ 

[1] ,São Paulo University Ribeirão Preto School of Medicine Department of OphthalmologyRibeirão Preto SP ,Brazil

关键词: Anti-angiogenic drugs;    Vitrectomy;    Diabetic retinopathy;    Retinal detachment;    Vitreous hemorrhage;    Inibidores da angiogênese;    Vitrectomia;    Retinopatia diabética;    Descolamento retiniano;    Hemorragia vítrea;   

DOI  :  10.1590/S0004-27492011000200017

来源: SciELO

【 摘 要 】

Advanced diabetic retinopathy with tractional retinal detachment or persistent vitreous hemorrhage often requires surgical treatment with pars plana vitrectomy. Despite advances in vitrectomy, surgery for complications of diabetic retinopathy can be a challenge and may be impaired by intense fibrovascular proliferation. Antiangiogenic drugs have been used for the treatment of diabetic retinopathy because of their inhibitory action on vascular endothelial growth factor. In this review, we discuss aspects related to the adjuvant use of these drugs in vitrectomy for complications of diabetic retinopathy. Bevacizumab shows beneficial effects regarding the surgical technique facilitation, but its long-term benefit still needs to be studied.

【 授权许可】

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