Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report

Arquivos Brasileiros de Oftalmologia

Ivana Lopes Romero²  Felipe Augusto Garcez De Campos¹  Renato Wendell Ferreira Damasceno¹  José Vital Filho¹  Simone Haber Duellberg Von Faber Bison¹ 

[1] ,Santa Casa de Misericórdia de São Paulo Departamento de Oftalmologia Setor de OculoplásticaSão Paulo SP ,Brasil

关键词: Plasmacytoma;    Orbital neoplasms;    Lacrimal apparatus;    Immunoglobulin kappa-chains;    Neoplasm invasiveness;    Multiple myeloma;    Tomography;    x-ray computed;    Human;    Female;    Adult;    Case reports;    Plasmocitoma;    Neoplasias orbitárias;    Aparelho lacrimal;    Cadeias kappa de imunoglobulina;    Invasividade neoplásica;    Mieloma múltiplo;    Tomografia computadorizada por raios x;    Humano;    Feminino;    Adulto;    Relatos de casos;   

DOI  :  10.1590/S0004-27492009000200020

来源: SciELO

【 摘 要 】

The authors present a rare case of plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma in a 42-year-old woman. The lesion was surgically removed and analyzed. Histopathological examination with immunostaining revealed it to be positive for immunoglobulin G and Kappa chains, demonstrating monoclonality. However, no abnormality was observed on serum electrophoresis, skeletal survey and bone marrow aspiration. Therefore, the tumor was diagnosed solitary plasmacytoma of bone. The patient was treated with external beam radiotherapy and has remained disease free for 5 years and 6 months until 2007, when she presented a pathological fracture due to multiple myeloma. Extensive medical work-up to rule out multiple myeloma or other malignant lymphoproliferative conditions involving orbit or ocular adnexa is needed when the diagnosis of solitary plasmacytoma of bone is suspected because treatment and prognosis are very different.

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