Clinical treatment of corneal infection due to Fonsecaea pedrosoi: case report

Arquivos Brasileiros de Oftalmologia

Ana Luisa Höfling-lima²  Josep Guarro¹  Denise De Freitas¹  Patricio Godoy¹  Josepa Gené¹  Luciene Barbosa De Souza¹  Luis Zaror¹  Andre C. Romano¹ 

[1] ,Universidade Federal de São Paulo Departamento de Oftalmologia

关键词: Corneal diseases;    Keratitis;    Eye injuries;    Eye infections;    fungal;    Antifungal agents;    Mitosporic fungi;    Case report;    Doenças da córnea;    Ceratite;    Traumatismos oculares;    Infecções oculares fúngicas;    Antimicóticos;    Fungos mitospóricos;    Relato de caso;   

DOI  :  10.1590/S0004-27492005000200023

来源: SciELO

【 摘 要 】

To report an unusual case of fungus keratitis due to Fonsecaea pedrosoi that developed after corneal trauma. Case report: A 18-year-old male presented with a corneal ulcer in the right eye, 28 days after a trauma with glass fragments. Corneal scrapings were collected for smears and culture. Dematiaceous hyphae were seen on wet mounts of the scrapings and dark pigmented colonies grew repetitively on the culture media; all colonies were identical, and were subsequently identified as Fonsecaea pedrosoi. Treatment was initiated with topical natamycin at one hour intervals, 200 mg oral ketoconazole per day and later changed to a combination of 200 mg ketoconazole and amphotericin B. In humid tropical regions Fonsecaea pedrosoi is one of the primary causes of human chronic cutaneous mycosis, chromoblastomycosis. Combination of systemic and topical antifungal medications may provide the best option for cure in corneal chromoblastomycosis.

【 授权许可】

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