In vitro antibiotic susceptibilities of ocular bacteria isolates from the cornea and conjunctiva to moxifloxacin, gatifloxacin and other fluoroquinolones

Arquivos Brasileiros de Oftalmologia

Ana Luisa Höfling-lima¹  Rubens Belfort Jr¹  Cecília Tobias Aguiar Moeller¹  Bruno Castelo Branco¹  Luciene Barbosa De Sousa¹  Denise De Freitas¹ 

[1] ,UNIFESP EPM Departamento de Oftalmologia

关键词: Quinolones;    Drug resistance;    microbial;    Eye infections;    Microbial sensitivity tests;    Cornea;    Conjunctiva;    Quinolonas;    Resistência microbianas a drogas;    Infecções oculares bacterianas;    Testes de sensibilidade microbiana;    Córnea;    Conjuntiva;   

DOI  :  10.1590/S0004-27492004000600007

来源: SciELO

【 摘 要 】

PURPOSE: To assess and compare the in vitro susceptibility of ocular bacterial isolates to fluoroquinolones, including moxifloxacin and gatifloxacin. METHODS: A total of 154 bacterial ocular isolates from keratitis and conjunctivitis were tested for sensitivity to the studied antibiotics, using the disk diffusion method. RESULTS: Of the 51 corneal isolates, 46 (90.2%) were sensitive to ciprofloxacin, 45 (88.2%) to ofloxacin and 41 (80.4%) to lomefloxacin. All corneal isolates were sensitive to moxifloxacin and gatifloxacin. Of the 103 bacterial conjunctival isolates, 101 (98.1%) and 103 (100%) were sensitive to gatifloxacin and moxifloxacin, respectively. Two strains of Streptococcus sp viridans group were resistant to gatifloxacin. A total of 82 (79.6%) specimens were sensitive to lomefloxacin, 89 (86.4%) and 96 (93.2%) to ciprofloxacin and ofloxacin, respectively. CONCLUSION: Fourth generation fluoroquinolones, herein exemplified by moxifloxacin and gatifloxacin, seem to be more effective than previous generation fluoroquinolones against frequently encountered organisms isolated from patients with bacterial keratitis and conjunctivitis.

【 授权许可】

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