Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature

Anais da Academia Brasileira de Ciências

Cristina P. Sousa¹  Isabel R. Dias¹  Mónica Lopez-peña¹  José A. Camassa¹  Paulo J. Lourenço¹  Fernando M. Judas¹  Manuela E. Gomes¹  Rui L. Reis¹ 

关键词: bone formation markers;    bone resorption markers;    delayed union;    fracture healing;    osteoclast regulatory proteins;    non-union process;    marcadores de formação óssea;    marcadores de reabsorção óssea;    atraso da união;    cicatrização das fraturas;    proteínas reguladoras de osteoclastos;    processo de não-união;   

DOI  :  10.1590/0001-3765201520150008

来源: SciELO

【 摘 要 】

Imaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for improving accuracy in diagnosing complications following bone fractures. The variation in the levels of bone turnover markers (BTMs) have been assessed with regard to there ability to predict impaired fracture healing at an early stage, nevertheless the conclusions of some studies are not consensual. In this article the authors have revised the potential of BTMs as early predictors of prognosis in adult patients presenting traumatic bone fractures but who did not suffer from osteopenia or postmenopausal osteoporosis. The available information from the different studies performed in this field was systematized in order to highlight the most promising BTMs for the assessment of fracture healing outcome.

【 授权许可】

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