Lymphocyte subset reference intervals in blood donors from northeastern Brazil

Anais da Academia Brasileira de Ciências

Alex J.l. Torres¹  PatrÍcia Cisneiros¹  Rosa Guedes¹  Maria Fernanda R. Grassi¹  Roberto Meyer¹  Maria T. Bendicho¹  Tais G.s.l. Lopes¹  Gabriela FÉlix¹  Eduardo M. Netto¹  Carlos Brites¹  Kiyoko Abe-sandes¹  Claudio BrandÃo¹  Neuza Alcantara-neves¹  Songeli M. Freire¹ 

关键词: lymphocyte subsets;    reference values;    flow cytometry;    Brazil;    blood donors;    Subgrupos de linfócitos;    valores de referências;    citometria de fluxo;    Brasil;    doadores de sangue;   

DOI  :  10.1590/0001-3765201520130114

来源: SciELO

【 摘 要 】

The reference intervals for leukocytes and lymphocytes currently used by most clinical laboratories present limitations as they are primarily derived from individuals of North American and European origin. The objective this study was to determine reference values for peripheral blood B lymphocytes, T lymphocyte subsets (CD4+, CD8+, naïve, memory, regulatory, TCRαβ and TCRγδ+) and NK cells from blood donors in Salvador-Bahia, Brazil. Results: The proportion of included male subjects was 73.7% and the median ages of males (34) and females (35) were found to be similar. Absolute counts total lymphocytes subsets to both gender was 1,956 (1,060-4,186) cells and relative values 34%. The T CD4+ and T CD8+ lymphocytes relative values was 51% (20-62) and 24% (9-28), respectively. The most statistically significant finding observed was a higher percentage of B lymphocytes (p=0.03) in females. Commonly cited subset reference intervals were found to be consistent with values in several populations from different geographic areas.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License