Soluble fractalkine in the plasma of fibromyalgia patients

Anais da Academia Brasileira de Ciências

Juan J. Garcia¹  Eduardo Ortega¹ 

关键词: fractalkine;    fibromyalgia;    biomarker;    chemokine;    monocyte;    fractalcina;    fibromialgia;    biomarcador;    quimiocina;    monócito;   

DOI  :  10.1590/0001-3765201420130081

来源: SciELO

【 摘 要 】

Fibromyalgia is a form of non-articular rheumatism in which inflammatory cytokines seem to be involved. However, there is still no analytical specific diagnostic criterion for this disease. The aim was to examine a possible role of fractalkine as a biomarker in fibromyalgia. Plasma levels of soluble fractalkine were compared between women diagnosed with fibromyalgia (n=17) and healthy women (n=10) as controls. Fractalkine released by monocytes was also evaluated. Fibromyalgia patients showed lower plasma fractalkine than healthy women. Since most inflammatory pathologies show elevated plasma levels of soluble fractalkine, the results may contribute towards a differential diagnosis for fibromyalgia.

【 授权许可】

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