Complete assignments of NMR data and assessment of trypanocidal activity of new eremantholide C derivatives

Anais da Academia Brasileira de Ciências

DÊnia A. SaÚde-guimarÃes¹  DÉlio S. Raslan¹  Egler Chiari¹  AlaÍde B. De Oliveira¹ 

关键词: Eremantholide C derivatives;    Lychnophora trichocarpha;    NMR;    sesquiterpene lactones;    trypanocidal activity;    Derivados de eremantolida C;    Lychnophora trichocarpha;    RMN;    lactonas sesquiter-pênicas;    atividade anti-Trypanosoma curuzi;   

DOI  :  10.1590/0001-3765201420140167

来源: SciELO

【 摘 要 】

Chemical transformations of eremantholide C (1), a sesquiterpene lactone that was isolated from Lychnophora trichocarpha Spreng. led to five new derivatives: 1′,2′- epoxyeremantholide C (2), 5-n-propylamine-4,5-dihydro-1′,2′-epoxyeremantholide C (3), 5-n-propylammonium-4,5-dihydro-1′,2′-epoxyeremantholide C chloride (4), 5-n-propylammonium-4,5-dihydroeremantolide C chloride (5) and 16-O-ethyleremantholide C (6). The structures of all these derivatives were assigned on the basis of IR, MS, 1H and 13C NMR data by 1D and 2D techniques. Eremantholide C and the derivatives 2, 4 and 5 were evaluated against trypomastigotes Y and CL strains of Trypanosoma cruzi. Eremantholide C completely inhibited the growth of both the parasites strains while all derivatives were partially active against the CL strain and inactive against the Y strain.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License