Acetone extract from Streptoverticillium sp., a bacterium isolated from Brazilian Cerrado soil, induces anti-inflammatory activity in mice

Anais da Academia Brasileira de Ciências

Rodrigo B. Da Cruz¹  Pablinny M. Galdino¹  Karlla G.b.d. Penna¹  Karen Hoffmann¹  Elson A. Costa¹  Luiz A.m. Bataus¹ 

关键词: Streptoverticillium;    anti-inflammatory effect;    nociceptive and inflammatory models;    phospholipase A2 activity;    Streptoverticillium;    efeito anti-inflamatorio;    modelos de inflamacao e nocicepcao;    fosfolipase A2;   

DOI  :  10.1590/S0001-37652013000200009

来源: SciELO

【 摘 要 】

The Streptoverticillium sp. Z1 is an actinomycete isolated from the soil under Cerrado vegetation, the extract of this strain was investigated in nociceptive and inflammatory models. The Streptoverticillium extract (ExS) 50 and 100 mg/kg (s.c.) produced a significant inhibition of acetic acid-induced abdominal writhings thereby demonstrating an anti-nociceptive effect. In the tail flick test the ExS (s.c.) was inactive. This result implited that ExS does not contain opioid-like compounds with central analgesic properties. In the inflammatory models, ExS 100 and 200 mg/kg (s.c.) were able to inhibit the croton oil-induced ear edema and, ExS 200 and 500 mg/kg (s.c.) inhibited the leukocyte migration on the carrageenan-induced peritonitis. The phospholipase A2 enzymatic assay showed that the anti-inflammatory activity of ExS was not due to direct effect on phospholipase A2 activity. These data suggest that Streptoverticillium sp. produces metabolites with anti-inflammatory effect and that these metabolites are unable to directly inhibit phospholipase A2 enzyme.

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