Cholinesterase as inflammatory markers in a experimental infection by Trypanosoma evansi in rabbits

Anais da Academia Brasileira de Ciências

Márcio M. Costa²  Aleksandro S. Da Silva¹  Francine C. Paim²  Raqueli França²  Guilherme L. Dornelles²  Gustavo R. Thomé¹  Jonas D.s. Serres¹  Roberta Schmatz¹  Rosélia M. Spanevello¹  Jamile F. Gonçalves¹  Maria Rosa C. Schetinger¹  Cinthia M.a. Mazzanti²  Sonia T.a. Lopes²  Silvia G. Monteiro¹ 

[1] ,Universidade Federal de Santa Maria Laboratório de Análises Clínicas Veterinária (LACVet) Santa Maria RS ,Brasil

关键词: acetylcholinesterase;    butyrylcholinesterase;    inflammation;    T. evansi;    acetilcolinesterase;    butirilcolinesterase;    inflamação;    T. evansi;   

DOI  :  10.1590/S0001-37652012005000062

来源: SciELO

【 摘 要 】

The aim of this study is to evaluate the role of cholinesterases as an inflammatory marker in acute and chronic infection by Trypanosoma evansi in rabbits experimentally infected. Twelve adult female New Zealand rabbits were used and divided into two groups with 6 animals each: control group (rabbits 1-6) and infected group (rabbits 7-12). Infected group received intraperitoneally 0.5 mL of blood from a rat containing 108 parasites per animal. Blood samples used for cholinesterases evaluation were collected on days 0, 2, 7, 12, 27, 42, 57, 87, 102 and 118 days post-inoculation (PI). Increased activity (P<0.05) of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) were observed in the blood on days 7 and 27, respectively and no differences were observed in cholinesterase activity in other periods. No significant difference in AChE activity (P>0.05) was observed in the encephalic structures. The increased activities of AChE and BChE probably have a pro-inflammatory purpose, attempting to reduce the concentration of acetylcholine, a neurotransmitter which has an anti-inflammatory property. Therefore, cholinesterase may be inflammatory markers in infection with T. evansi in rabbits.

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