Hepatoprotective, cardioprotective, and renal-protective effects of organic and conventional grapevine leaf extracts (Vitis labrusca var. Bordo) on Wistar rat tissues

Anais da Academia Brasileira de Ciências

Lívia S. Oliboni²  Caroline Dani²  Cláudia Funchal¹  João A. Henriques²  Mirian Salvador² 

[1] ,Universidade de Caxias do Sul Instituto de Biotecnologia Laboratório de Estresse Oxidativo e AntioxidantesCaxias do Sul RS ,Brasil

关键词: antioxidant activity;    grapevine leaves;    hepatoprotective;    cardioprotective;    renal-protective;    Vitis labrusca;    atividade antioxidante;    folhas de videiras;    hepatoproteção;    cardioproteção;    renal proteção;    Vitis labrusca;   

DOI  :  10.1590/S0001-37652011000400027

来源: SciELO

【 摘 要 】

The purpose of this study was to evaluate the beneficial effects of organic and conventional grapevine (Vitis labrusca L.) leaf extracts in reducing hydrogen peroxide-induced stress in the liver, heart and kidney of Wistar rats by measuring lipids and proteins damages (carbonyl assay), as well as the activity of the antioxidant enzymes superoxide dismutase and catalase. The preincubation with 5 mg/mL of organic and conventional grapevine (Vitis labrusca L.) leaf extracts prevented both lipids and proteins oxidative damages in all tissues analyzed. The organic leaf extract was able to restore superoxide dismutase (kidney and liver) and catalase (heart) activities, which were modified by the treatment with H2O2. The conventional extract was able to restore only the catalase activity in liver and heart tissues. The beneficial effects of the V labrusca leaf extract shown in this study could probably be important for formulating dietary supplements, as well as for developing new ingredients with improved antioxidant properties from other plant sources.

【 授权许可】

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