The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks

Anais da Academia Brasileira de Ciências

Iván Izquierdo²  Martín Cammarota²  Weber C. Da Silva²  Lia R.m. Bevilaqua²  Janine I. Rossato²  Juliana S. Bonini²  Pamela Mello²  Fernando Benetti²  Jaderson C. Costa²  Jorge H. Medina¹ 

[1] ,Pontifícia Universidade Católica do Rio Grande do Sul Instituto de Pesquisas Biomédicas Centro de MemóriaPorto Alegre RS ,Brasil

关键词: long-term potentiation;    hippocampus;    declarative memory;    aversive memory;    potenciação de longa duração;    hipocampo;    memória declarativa;    memória aversiva;   

DOI  :  10.1590/S0001-37652008000100007

来源: SciELO

【 摘 要 】

Long-term potentiation (LTP) is the enhancement of postsynaptic responses for hours, days or weeks following the brief repetitive afferent stimulation of presynaptic afferents. It has been proposed many times over the last 30 years to be the basis of long-term memory. Several recent findings finally supported this hypothesis: a) memory formation of one-trial avoidance learning depends on a series of molecular steps in the CA1 region of the hippocampus almost identical to those of LTP in the same region; b)hippocampal LTP in this region accompanies memory formation of that task and of another similar task. However, CA1 LTP and the accompanying memory processes can be dissociated, and in addition plastic events in several other brain regions(amygdala, entorhinal cortex, parietal cortex) are also necessary for memory formation of the one-trial task, and perhaps of many others.

【 授权许可】

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