Antifungal activity of the extracts and saponins from Sapindus saponaria L.

Anais da Academia Brasileira de Ciências

Joyce K. Tsuzuki²  Terezinha I.e. Svidzinski¹  Cristiane S. Shinobu¹  Luiz F.a. Silva¹  Edson Rodrigues-filho¹  Diógenes A.g. Cortez²  Izabel C.p. Ferreira² 

[1] ,Universidade Estadual de Maringá Departamento de Farmácia e Farmacologia Maringá PR ,Brasil

关键词: Sapindaceae;    Sapindus saponaria;    saponins;    antifungal activity;    Candida;    Sapindaceae;    Sapindus saponaria;    saponinas;    atividade antifúngica;    Candida;   

DOI  :  10.1590/S0001-37652007000400002

来源: SciELO

【 摘 要 】

Extracts from the dried pericarp of Sapindus saponaria L. (Sapindaceae) fruits were investigated for their antifungal activity against clinical isolates of yeasts Candida albicans and C. non-albicans from vaginal secretions of women with Vulvovaginal Candidiasis. Four clinical isolates of C. albicans, a single clinical isolated of each of the species C. parapsilosis, C. glabrata, C. tropicalis, and the strain of C. albicans ATCC 90028 were used. The hydroalcoholic extract was bioactivity-directed against a clinical isolate of C. parapsilosis, and showed strong activity. The n-BuOH extract and one fraction showed strong activity against all isolates tested. Further column-chromatography on silica gel separation of this fraction afforded two pure triterpene acetylated saponins: 3-O-(4-acetyl-beta-D-xylopyranosyl)-(1->3)-alpha-Lrhamnopyranosyl-(1->2)-alpha-L-arabinopyranosyl-hederagenin (1) and 3-O-(3,4-di-acetyl-beta-D-xylopyranosyl)-(1->3)-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabynopyranosyl-hederagenin (2). The structures of the compounds were based on spectral data (¹H and 13C NMR, HSQC, HMBC and MS), and on with literature. The saponins isolated showed strong activity against C. parapsilosis.

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