Complete ¹H and 13C NMR assignments and anti fungal activity of two 8-hydroxy flavonoids in mixture

Anais da Academia Brasileira de Ciências

Susana Johann²  Artur Smânia-jr²  Moacir G. Pizzolatti¹  Jan Schripsema¹  Raimundo Braz-filho¹  Alexsandro Branco¹ 

[1] ,Universidade Federal de Santa Catarina Departamento de Microbiologia e Parasitologia Laboratório de AntibióticosFlorianópolis SC ,Brasil

关键词: polymethoxyflavones;    antifungal activity;    Citrus aurantifolia;    polimetoxiflavonas;    atividade antifúngica;    Citrus aurantifolia;   

DOI  :  10.1590/S0001-37652007000200004

来源: SciELO

【 摘 要 】

A mixture of the two new flavonols 8-hydroxy-3, 4', 5, 6, 7-pentamethoxyflavone (1) and 8-hydroxy-3, 3', 4', 5, 6, 7-hexamethoxyflavone (2) was isolated from a commercial sample of Citrus aurantifolia. An array of one- (¹HNMR, {¹H}-13C NMR, and APT-13C NMR) and two-dimensional NMR techniques (COSY, NOESY, HMQC and HMBC) was used to achieve the structural elucidation and the complete ¹H and 13C chemical shift assignments of these natural compounds. In addition, the antifungal activity of these compounds against phytopathogenic and human pathogenic fungi was investigated.

【 授权许可】

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