Genes and chromosomes: control of development

Anais da Academia Brasileira de Ciências

Oleg Serov¹  Irina Serova¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Biofísica Carlos Chagas Filho Rio de Janeiro RJ ,Brasil

关键词: epigenetic regulation;    developmental genes;    genetic networks;    variegated position effect;    chromosome territories;    organization of the interphase nucleus;    regulação epigenética;    genes de desenvolvimento;    redes genéticas;    efeito posicional variegado;    territórios cromossômicos;    organização do núcleo interfásico;   

DOI  :  10.1590/S0001-37652004000300007

来源: SciELO

【 摘 要 】

The past decade has witnessed immense progress in research into the molecular basis behind the developmental regulation of genes. Sets of genes functioning under hierarchical control have been identified, evolutionary conserved systems of genes effecting the cell-to-cell transmission of transmembrane signals and assigned a central role in morphogenesis have been intensively studied; the concept of genomic regulatory networks coordinating expression of many genes has been introduced, to mention some of the major breakthroughs. It should be noted that the temporal and tissue-specific parameters of gene expression are correctly regulated in development only in the context of the chromosome and that they are to a great extent dependent on the position of the gene on the chromosome or the interphase nucleus. Moreover epigenetic inheritance of the gene states through successive cell generations has been conducted exclusively at the chromosome level by virtue of cell or chromosome memory. The ontogenetic memory is an inherent property of the chromosome and cis-regulation has a crucial role in its maintenance.

【 授权许可】

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