New enamine derivatives of lapachol and biological activity

Anais da Academia Brasileira de Ciências

Mailcar F. Oliveira²  Telma L.g. Lemos²  Marcos C. De Mattos²  Taciana A. Segundo¹  Gilvandete M.p. Santiago¹  Raimundo Braz-filho¹ 

[1],Universidade Federal do Ceará Departamento de Química Orgânica e Inorgânica Fortaleza Ceará ,Brazil

关键词: lapachol;    enamine derivatives;    biological activities;    lapachol;    derivados enamínicos;    atividades biológicas;   

DOI  :  10.1590/S0001-37652002000200004

来源: SciELO

【 摘 要 】

A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells.

【 授权许可】

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