Short- and long-term memory: differential involvement of neurotransmitter systems and signal transduction cascades

Anais da Academia Brasileira de Ciências

MÔnica R.m. Vianna²  Luciana A. Izquierdo²  Daniela M. Barros²  Roger Walz²  Jorge H. Medina¹  IvÁn Izquierdo² 

[1] ,Universidade Federal do Rio Grande do Sul ICBS Departamento de BioquímicaPorto Alegre RS ,Brasil

关键词: Short-term memory;    long-term memory;    hippocampus;    PKA;    PKC;    MAPK;   

DOI  :  10.1590/S0001-37652000000300009

来源: SciELO

【 摘 要 】

Since William James (1890) first distinguished primary from secondary memory, equivalent to short- and long-term memory, respectively, it has been assumed that short-term memory processes are in charge of cognition while long-term memory is being consolidated. From those days a major question has been whether short-term memory is merely a initial phase of long-term memory, or a separate phenomena. Recent experiments have shown that many treatments with specific molecular actions given into the hippocampus and related brain areas after one-trial avoidance learning can effectively cancel short-term memory without affecting long-term memory formation. This shows that short-term memory and long-term memory involve separate mechanisms and are independently processed. Other treatments, however, influence both memory types similarly, suggesting links between both at the receptor and at the post-receptor level, which should not be surprising as they both deal with nearly the same sensorimotor representations. This review examines recent advances in short- and long-term memory mechanisms based on the effect of intra-hippocampal infusion of drugs acting upon neurotransmitter and signal transduction systems on both memory types.

【 授权许可】

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