Synthesis of novel 6,7-dimethoxy-4-anilinoquinolines as potent c-Met inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Lei Wang¹  Lei Shi¹  Zi-Dan Ye¹  Hong-Xia Tie¹  Qing-Wen Zhang¹  Chang Shen¹ 

[1] Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. Chin;

关键词: c-Met;    inhibitor;    6,7-Dimethoxy-4-anilinoquinoline;    synthesis;    antitumour;   

DOI  :  10.1080/14756366.2018.1533822

来源: publisher

【 摘 要 】

HGF/c-Met signalling pathway plays an important role in the development of cancers. A series of 6,7-dimethoxy-4-anilinoquinolines possessing benzimidazole moiety were synthesised and identified as potent inhibitors of the tyrosine kinase c-Met. Their in vitro biological activities against three cancer cell lines (A549, MCF-7, and MKN-45) were also evaluated. Most of these compounds exhibited moderate to remarkable potency. Among them, compound 12n showed the most potent inhibitory activity against c-Met with IC50 value of 0.030 ± 0.008 µM and it also showed excellent anticancer activity against the tested cancer cell lines at low micromolar concentration. Molecular docking verified the results and revealed the possible binding mode of the most promising compound 12n into the ATP-binding site of c-Met kinase.

【 授权许可】

CC BY