Albumin-based cancer therapeutics for intraperitoneal drug delivery: a review

Drug Delivery

Leen Van de Sande¹  Wim Ceelen¹  Wouter Willaert¹  Sarah Cosyns¹ 

[1] Laboratory of Experimental Surgery, Department of Human Structure and Repair, Ghent University, Ghent, Belgium;Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgiu;

关键词: Albumin;    intraperitoneal delivery;    peritoneal metastasis;    chemotherapy;    peritoneum;   

DOI  :  10.1080/10717544.2019.1704945

来源: publisher

【 摘 要 】

Albumin is a remarkable carrier protein with multiple cellular receptor and ligand binding sites, which are able to bind and transport numerous endogenous and exogenous compounds. The development of albumin-bound drugs is gaining increased importance in the targeted delivery of cancer therapy. Intraperitoneal (IP) drug delivery represents an attractive strategy for the local treatment of peritoneal metastasis (PM). PM is characterized by the presence of widespread metastatic tumor nodules on the peritoneum, mostly originating from gastro-intestinal or gynaecological cancers. Albumin as a carrier for chemotherapy holds considerable promise for IP delivery in patients with PM. Data from recent (pre)clinical trials suggest that IP albumin-bound chemotherapy may result in superior efficacy in the treatment of PM compared to standard chemotherapy formulations. Here, we review the evidence on albumin-bound chemotherapy with a focus on IP administration and its efficacy in PM.

【 授权许可】

CC BY