Preoperative maximum standardized uptake value and carbohydrate antigen 19–9 were independent predictors of pathological stages and overall survival in Chinese patients with pancreatic duct adenocarcinoma

BMC Cancer

Ruiquan Zhou¹  Yong Xu²  Chenggang Li²  Yuanxing Gao²  Zhiming Zhao²  Xinjin Gu²  Rong Liu³ 

[1] 0000 0000 9878 7032, grid.216938.7, School of Medicine, Nankai University, 300071, Tianjin, China;0000 0004 1761 8894, grid.414252.4, Department of Hepatobiliary and Pancreatic Surgical Oncology, Chinese People’s Liberation Army General Hospital, 100853, Beijing, China;0000 0004 1761 8894, grid.414252.4, Department of Hepatobiliary and Pancreatic Surgical Oncology, Chinese People’s Liberation Army General Hospital, 100853, Beijing, China;0000 0000 9878 7032, grid.216938.7, School of Medicine, Nankai University, 300071, Tianjin, China;

关键词: Carbohydrate antigen 19–9;    Maximum standardized uptake value;    Pathological stages;    Overall survival;    Pancreatic duct adenocarcinoma;    Pancreaticoduodenectomy;   

DOI  :  10.1186/s12885-019-5691-4

来源: publisher

【 摘 要 】

BackgroundPurpose of this study was to analyze whether preoperative maximum standardized uptake value (SUVmax) and carbohydrate antigen 19–9 (CA19–9) levels might provide prognostic information in Chinese patients with pancreatic duct adenocarcinoma (PDAC) after pancreaticoduodenectomy (PD).MethodsStandard PD was performed on 109 patients with PDAC by the same operative team, and all patients received preoperative positron emission tomography/computed tomography examination and blood test.ResultsPatients had a mean age of 59 ± 9.35 years. Females accounted for 38.5%. Mean levels of SUVmax, carcino-embryonic antigen (CEA) and CA19–9 were 5.70 ± 2.76, 3.95 ± 4.16ng/mL and 321.62 ± 780.71kU/L. In univariate Logistic regression analysis, preoperative SUVmax, CEA and CA19–9 levels (p < 0.05 for all) rather than other preoperative variables (p > 0.05 for all) were significantly related to AJCC stages. Multivariate Logistic regression analysis showed that preoperative SUVmax and CA19–9 levels (p < 0.05 for all) rather than other preoperative variables (p > 0.05 for all) were significantly associated with AJCC stages. Mean overall survival (OS) was 21 ± 14.50 months. In univariate Cox regression analysis, age, SUVmax, CEA and CA19–9 levels before operation (p < 0.05 for all) rather than other preoperative variables (p > 0.05 for all) were significantly related to OS. Multivariate Cox regression analysis showed that age, SUVmax and CA19–9 levels before operation (p < 0.05 for all) rather than other preoperative variables (p > 0.05 for all) were significantly associated with OS.ConclusionsThis study demonstrated that preoperative SUVmax and CA19–9 levels independently predicted pathological stages and OS of patients with PDAC after PD. These preoperative variables might have significant prognostic implication in patients with PDAC after PD. Patients with abnormal SUVmax and CA19–9 levels should be paid special attention to in operative strategy and perioperative management.

【 授权许可】

CC BY