Haemolytic anaemia and hepatocitolysis associated with hypermagnesaemia by repeated exposures to copper–calcium fungicides

Journal of Enzyme Inhibition and Medicinal Chemistry

Bogdan Ioan Coculescu¹  Constantin Bălăeţ²  Gabi Valeriu Dincă³  Gheorghe Manole⁴  Maria Bălăeţ⁵ 

[1] Faculty of General Nursing, Bioterra University, Bucharest, Romania;Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania;Center for Military Medical Scientific Research, Bucharest, Romania;Faculty of General Nursing, Bioterra University, Bucharest, Romania;Lil Med Clinic, Bucharest, Romania;Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania;Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania;Clinical Hospital Colentina, Bucharest, Romani;Imperial College London, London, UK;

关键词: Copper–calcium fungicide;    hypercupraemia;    oxidative stress;    haemolysis;    ineffective erythropoiesis;    hypermagnesaemia;    hepatocytic cytolysis;   

DOI  :  10.1080/14756366.2017.1409745

来源: publisher

【 摘 要 】

For the medical practice, our manuscript acts as a signal, despite only presenting three cases which feature the association between hepatocytolysis, haemolysis and hypermagnesaemia. This clinical–biologic triad was highlighted with the workers who through the nature of their profession were exposing themselves periodically to vapours which contained copper sulphate neutralised with calcium hydroxide, a fungicide used for fruit trees. We are exclusively assessing the haematological perturbation. In this aetiological context, the generating mechanism for haemolysis is very probable biochemical, where hypercupraemia interferes with cellular antioxidant defence mechanisms. Hypothetically, the role of the redox homeostasis disorder in the intravascular destruction of erythrocytes is sustained, and particularly the coexistence of cell cytolysis in the medullary erythroid compartment, which can be assimilated with a possible ineffective erythropoiesis.

【 授权许可】

CC BY