Comparison of blood carbonic anhydrase activity of athletes performing interval and continuous running exercise at high altitude

Journal of Enzyme Inhibition and Medicinal Chemistry

Deniz Ekinci¹  Murat Senturk²  Murat Tas³  Murat Akyuz³  Metin Bayram⁴  Veysal Comakli⁵  Esra Senturk⁵  Ramazan Demirdag⁵  Claudiu T. Supuran⁶ 

[1] Faculty of Agriculture, Ondokuz Mayıs University, Samsun, Turkey;Faculty of Pharmacy, Agri Ibrahim Cecen University, Agri, Turkey;Faculty of Sport Sciences, Manisa Celal Bayar University, Manisa, Turkey;Physical Education Sports High School, Agri Ibrahim Cecen University, Agri, Turkey;School of Health Services, Agri Ibrahim Cecen University, Agri, Turkey;Section of Pharmaceutical Chemistry, Neurofarba Department, University of Florence, Firenze, Ital;

关键词: Carbonic anhydrase;    exercise training;    enzyme inhibition;   

DOI  :  10.1080/14756366.2018.1545768

来源: publisher

【 摘 要 】

The effects of high-intensity interval and continuous exercise on erythrocytes carbonic anhydrase (CA, EC 4.2.1.1) activity levels were scarcely investigated up until now. Here we present a study focused on the CA activity from erythrocytes of athletes experiencing interval and continuous training for 6 weeks, during cold weather and at high altitude (> 1600 m). We observed a 50% increase in the blood CA activity at the second week after initiation of the training in both interval and continuos running groups, whereas the control group did not experience any variation in the enzyme activity levels. In the trained individuals a mild decrease in their body mass, BMI and an increasedwere also observed. The CA activity returned at the basal values after 4–6 weeks after the training started, probably proving that a metabolic compensation occurred without the need of an enhanced enzyme activity. The unexpected 50% rise of activity for an enzyme which acts as a very efficient catalyst for CO2 hydration/bicarbonate dehydration, such as the blood CA, deserves further investigations for better understanding the physiologic basis of this phenomenon.

【 授权许可】

CC BY