Lipid-chitosan hybrid nanoparticles for controlled delivery of cisplatin

Drug Delivery

Vladimir Torchilin¹  Jiayi Pan¹  Nina Filipczak²  Muhammad Muzamil Khan³  Nayab Tahir⁴  Hassan Shah⁵  Asadullah Madni⁵ 

[1] Center of Pharmaceutical Biotechnology and Nanomedicines, Northeastern University, Boston, MA, USA;Center of Pharmaceutical Biotechnology and Nanomedicines, Northeastern University, Boston, MA, USA;Department of Biotechnology, Laboratory of Lipids and Liposomes, University of Wroclaw, Wroclaw, Poland;Center of Pharmaceutical Biotechnology and Nanomedicines, Northeastern University, Boston, MA, USA;Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan;College of Pharmacy, University of Sargodha, Sargodha, Pakista;Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan;

关键词: Cisplatin;    lipid-polymer hybrid nanoparticles;    chitosan;    controlled release;    ovarian cancer;    pharmacokinetics;   

DOI  :  10.1080/10717544.2019.1642420

来源: publisher

【 摘 要 】

Lipid-polymer hybrid nanoparticles (LPHNP) are delivery systems for controlled drug delivery at tumor sites. The superior biocompatible properties of lipids and structural advantages of polymers can be obtained using this system for controlled drug delivery. In this study, cisplatin-loaded lipid-chitosan hybrid nanoparticles were formulated by the single step ionic gelation method based on ionic interaction of positively charged chitosan and negatively charged lipid. Formulations with various chitosan to lipid ratios were investigated to obtain the optimal particle size, encapsulation efficiency, and controlled release pattern. Transmission electron microscope and dynamic light scattering analysis demonstrated a size range of 181–245 nm and a zeta potential range of 20–30 mV. The stability of the formulation was demonstrated by thermal studies. Cytotoxicity and cellular interaction of cisplatin-loaded LPHNP were investigated using in vitro cell-based assays using the A2780 ovarian carcinoma cell line. The pharmacokinetics study in rabbits supported a controlled delivery of cisplatin with enhanced mean residence time and half-life. These studies suggest that cisplatin loaded LPHNP have promise as a platform for controlled delivery of cisplatin in cancer therapy.

【 授权许可】

CC BY