Improving cellular uptake of therapeutic entities through interaction with components of cell membrane

Drug Delivery

Pengwei Chen¹  Fandong Kong¹  Renshuai Zhang²  Xiaofei Qin²  Guojun Pan³ 

[1] Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agriculture Sciences, Haikou, P.R. China;Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing, P.R. China;School of Life Sciences, Taishan Medical University, Tai’an, P.R. Chin;

关键词: Cellular uptake;    delivery systems;    plasma membrane;    pro-drugs;    disulfide exchange;   

DOI  :  10.1080/10717544.2019.1582730

来源: publisher

【 摘 要 】

Efficient cellular delivery of biologically active molecules is one of the key factors that affect the discovery and development of novel drugs. The plasma membrane is the first barrier that prevents direct translocation of chemic entities, and thus obstructs their efficient intracellular delivery. Generally, hydrophilic small molecule drugs are poor permeability that reduce bioavailability and thus limit the clinic application. The cellular uptake of macromolecules and drug carriers is very inefficient without external assistance. Therefore, it is desirable to develop potent delivery systems for achieving effective intracellular delivery of chemic entities. Apart from of the types of delivery strategies, the composition of the cell membrane is critical for delivery efficiency due to the fact that cellular uptake is affected by the interaction between the chemical entity and the plasma membrane. In this review, we aimed to develop a profound understanding of the interactions between delivery systems and components of the plasma membrane. For the purpose, we attempt to present a broad overview of what delivery systems can be used to enhance the intracellular delivery of poorly permeable chemic entities, and how various delivery strategies are applied according to the components of plasma membrane.

【 授权许可】

CC BY