期刊论文详细信息
Drug Delivery | |
Co-delivery of metformin and levofloxacin hydrochloride using biodegradable thermosensitive hydrogel for the treatment of corneal neovascularization | |
Xiuli Xie1  Yuqiong Zhu1  Dong Liu1  Sihan Li1  Yijun Liu1  Fangming Zhu2  Weirong Chen3  Qianni Wu3  Haotian Lin3  | |
[1]GDHPPCLab, School of Chemistry, Sun Yat–Sen University, Guangzhou, China | |
[2]GDHPPCLab, School of Chemistry, Sun Yat–Sen University, Guangzhou, China | |
[3]Key Lab for Polymer Composite and Functional Materials of Ministry of Education, School of Chemistry, Sun Yat–Sen University, Guangzhou, Chin | |
[4]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China | |
关键词: Thermosensitive hydrogel; corneal neovascularization; metformin; subconjunctival injection; synergistic effect; | |
DOI : 10.1080/10717544.2019.1609623 | |
来源: publisher | |
【 摘 要 】
Corneal neovascularization (CNV) is one of the major causes of severe disorders in ocular surface. Subconjunctival administration provides a localized and effective delivery of anti-angiogenic agents to inhibit neovascularization. In the present study, the ABA triblock copolymer of poly(D,L-lactic-co-glycolic acid)-block-poly(ethylene glycol)-block-poly(D,L-lactic-co-glycolic acid) (PLGA-PEG-PLGA) was used as a sustained drug delivery carrier for metformin (MET) and levofloxacin hydrochloride (LFH). Both drugs and PLGA-PEG-PLGA copolymers could be easily dissolved in water at low or room temperature and the mixed solution could form a drug-loaded thermosensitive hydrogel in terms of body temperature response. The in vitro release investigation displayed a sustained release of MET and LFH from the formulation for one month. The in vivo efficacy of subconjunctival injection of the MET + LFH loaded thermosensitive hydrogel in inhibiting CNV was evaluated on a mouse model of corneal alkali burn. Compared with the single administration of MET or LFH loaded thermosensitive hydrogel, the MET + LFH loaded thermosensitive hydrogel remarkably inhibited the formation of CNV. The sustained release of MET and an antibiotic (LFH) provides synergistic therapeutic outcome. As a result, the co-delivery of MET and LFH using PLGA-PEG-PLGA thermosensitive hydrogel by subconjunctival injection has great potential for ocular anti-angiogenic therapy.【 授权许可】
CC BY
【 预 览 】
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RO202004238124381ZK.pdf | 1372KB | download |