Predictors of distant metastasis in parotid acinic cell carcinoma

BMC Cancer

Xu Zhang¹  Junfu Wu¹  Qigen Fang¹  Wei Du¹ 

[1] 0000 0004 1799 4638, grid.414008.9, Department of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan Province, People’s Republic of China;

关键词: Parotid cancer;    Intraparotid node metastasis;    Acinic cell carcinoma;    High-grade transformation;    Distant metastasis;   

DOI  :  10.1186/s12885-019-5711-4

来源: publisher

【 摘 要 】

BackgroundDistant metastasis (DM) is a common treatment failure pattern in acinic cell carcinoma (AciCC) of the major salivary glands; therefore, the main goal of this study was to analyse the predictors of DM in parotid AciCC.MethodsConsecutive patients with surgically treated parotid AciCC who were followed for at least 5 years were retrospectively reviewed. Data regarding age, sex, TNM stage, pathologic characteristics, surgical treatment, and follow-up examinations were collected and analysed. The primary end-point was DM control (DMC); the DMC survival was calculated from the date of surgery to the date of event or the latest follow-up examination and analysed by the Kaplan-Meier method. Independent prognostic factors were evaluated by the Cox proportional hazards method.ResultsA total of 144 patients were included. Positive intraparotid nodes (IPNs) were noted in 34 (31.8%) patients. High-grade transformation was noted in 12 (8.3%) patients. A total of 83 (57.6%) patients underwent neck dissection, and neck node metastasis was proven in 37 (44.6%, 37/83) patients. The 10-year DMC rate was 86%. The Cox model analysis confirmed IPN metastasis (1.854 [1.061–4.144], p = 0.011) and high-grade transformation (4.219 [1.948–15.553], p < 0.001) as independent predictive factors of the DMC survival.ConclusionIPN metastasis and high-grade transformation are independent prognostic factors of the DMC survival.

【 授权许可】

CC BY