Efficacy of the In2Care® auto-dissemination device for reducing dengue transmission: study protocol for a parallel, two-armed cluster randomised trial in the Philippines

Trials

Richard E. Paul¹  Edward Thomsen²  Tom Toner²  Marianette T. Inobaya³  Ferdinand Salazar⁴  Ariza Aguila⁴  Jason Angeles⁴  Ava Kristy Sy⁵  Michael J. Bangs⁶ 

[1] 0000 0001 2353 6535, grid.428999.7, Functional Genetics of Infectious Diseases Unit, Institut Pasteur, Paris, France;0000 0001 2112 9282, grid.4444.0, Génomique évolutive, modélisation et santé UMR 2000, Centre National de la Recherche Scientifique (CNRS), Paris, France;0000 0004 1936 9764, grid.48004.38, Liverpool School of Tropical Medicine, Liverpool, UK;0000 0004 4690 374X, grid.437564.7, Department of Epidemiology and Biostatistics, Research Institute for Tropical Medicine, Filinvest City Alabang, Muntinlupa City, Philippines;0000 0004 4690 374X, grid.437564.7, Department of Medical Entomology, Research Institute for Tropical Medicine, Filinvest City Alabang, Muntinlupa City, Philippines;0000 0004 4690 374X, grid.437564.7, Department of Virology, Research Institute for Tropical Medicine, Filinvest City Alabang, Muntinlupa City, Philippines;PT Freeport Indonesia/International SOS, Kuala Kencana, Indonesia;0000 0001 0944 049X, grid.9723.f, Kasetsart University, Bangkok, Thailand;

关键词: Auto-dissemination;    Pyriproxyfen;    Beauvaria;    Dengue;    Aedes aegypti;   

DOI  :  10.1186/s13063-019-3376-6

来源: publisher

【 摘 要 】

BackgroundMosquito-borne viruses are imposing an ever increasing health burden worldwide. In addition to the recent Zika and chikungunya virus epidemics, dengue viruses have become the fastest growing problem with a 40-fold increase in the number of reported cases over the past five decades. Current mosquito control techniques involving larval source reduction, larviciding, and space spray of adulticides are costly, laborious, and of debatable efficacy. There remains an urgent need for the development of intervention methods that can be reasonably implemented in the context of modern day urbanisation. Auto-dissemination (AD) of insecticide by adult mosquitoes offers a potentially practical and useful tool in an integrated vector control programme. Recently, an immediately employable AD device, the In2Care® mosquito trap, has been commercialised and shows promise as an effective tool. However, there remains a lack of demonstration of epidemiological efficacy.Methods/designThis trial aims to assess the extent to which implementation of In2Care® mosquito traps can reduce vector Aedes (Stegomyia) spp. adult mosquito densities and dengue virus transmission as measured by sequential sero-conversion rates in children 6–16 years of age in a dengue endemic location: Lipa City, Philippines. To achieve this, we will carry out a parallel, two-armed cluster randomised trial evaluating AD efficacy for reducing the incidence of dengue over a 2-year period with 4 consecutive months of vector control during peak dengue transmission each year.DiscussionFor decades, it has been commonly accepted that an integrated approach to mosquito control is required. The World Health Organization (WHO) Global Strategic Framework for Integrated Vector Management recommends a range of interventions, in combination, to increase control impact to reduce transmission. This efficacy trial of the first commercial product using the AD approach will be informative in assessing the general utility of AD in reducing not only adult vector densities but, more importantly, reducing the incidence of dengue. The AD technique may complement source reduction and larviciding campaigns by more efficiently targeting the most productive containers and those beyond human reach. If successful, this mosquito control strategy could prove an invaluable tool in the fight against urban mosquito vectors and a reduction in the burden of associated disease.Trial registrationISRCTN44272773. Registered on 31 January 2019.

【 授权许可】

CC BY