Delivery of magnetic micro/nanoparticles and magnetic-based drug/cargo into arterial flow for targeted therapy

Drug Delivery

Amir Sanati-Nezhad¹  Milad Shamsi¹  Mahsa Saadat²  Reza Kamali³  Mohammad K. D. Manshadi⁴  Mehdi Mohammadi⁵  Morteza Dejam⁶ 

[1] Department of Biological Science, University of Calgary, Calgary, Alberta, Canada;Center for Bioengineering Research and Education, University of Calgary, Calgary, Alberta, Canada;Department of Chemical Engineering, College of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran;Department of Mechanical Engineering, Shiraz University, Shiraz, Ira;Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Alberta, Canada;Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Alberta, Canada;Department of Biological Science, University of Calgary, Calgary, Alberta, Canada;Center for Bioengineering Research and Education, University of Calgary, Calgary, Alberta, Canada;Department of Petroleum Engineering College of Engineering and Applied Science, University of Wyoming, Laramie, WY, USA;

关键词: Magnetic drug targeting;    drug/cargo delivery;    artery;    cancer therapy;    computational fluid dynamics;    numerical simulation;   

DOI  :  10.1080/10717544.2018.1497106

来源: publisher

【 摘 要 】

Magnetic drug targeting (MDT) and magnetic-based drug/cargo delivery are emerging treatment methods which attracting the attention of many researchers for curing different cancers and artery diseases such as atherosclerosis. Herein, computational studies are accomplished by utilizing magnetic approaches for cancer and artery atherosclerosis drug delivery, including nanomagnetic drug delivery and magnetic-based drug/cargo delivery. For the first time, the four-layer structural model of the artery tissue and its porosity parameters are modeled in this study which enables the interaction of particles with the tissue walls in blood flow. The effects of parameters, including magnetic field strength (MFS), magnet size, particle size, the initial position of particles, and the relative magnetic permeability of particles, on the efficacy of MDT through the artery walls are characterized. The magnetic particle penetration into artery layers and fibrous cap (the covering layer over the inflamed part of the artery) is further simulated. The MDT in healthy and diseased arteries demonstrates that some of the particles stuck in these tissues due to the collision of particles or blood flow deviation in the vicinity of the inflamed part of the artery. Therefore the geometry of artery and porosity of its layers should be considered to show the real interaction of particles with the artery walls. Also, the results show that increasing the particles/drug/cargo size and MFS leads to more particles/drug/cargo retention within the tissue. The present work provides insights into the decisive factors in arterial MDT with an obvious impact on locoregional cancer treatment, tissue engineering, and regenerative medicine.

【 授权许可】

CC BY