Zinc oxide end-capped Fe3O4@mSiO2 core-shell nanocarriers as targeted and responsive drug delivery system for chemo-/ions synergistic therapeutics

Drug Delivery

Hicham Fenniri¹  Ping Zhao²  Xiangyu Sun²  Zhihui Liao²  Yahui Li³  Xiaoliang Qi³  Minchao Liu⁴  Jianliang Shen⁵  Yuna Qian⁶ 

[1] Department of Chemical Engineering, Northeastern University, Boston, MA, USA;Department of Bioengineering, Northeastern University, Boston, MA, USA;Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, US;School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, China;School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, China;School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, China;School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, China;School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, China;Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China;Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China;

关键词: Magnetic mesoporous silica nanoparticles;    ZnO;    daunomycin;    pH-responsive;    synergistic effects;   

DOI  :  10.1080/10717544.2019.1642419

来源: publisher

【 摘 要 】

Multifunctional core-shell nanocarriers based on zinc oxide (ZnO)-gated magnetic mesoporous silica nanoparticles (MMSN) were prepared for cancer treatment through magnetic targeting and pH-triggered controlled drug release. Under an external magnetic field, the MMSN could actively deliver chemotherapeutic agent, daunomycin (DNM), to the targeted sites. At neutral aqueous, the functionalized MMSN could stably accommodate the DNM molecules since the mesopores were capped by the ZnO gatekeepers. In contrast, at the acid intercellular environment, the gatekeepers would be removed to control the release of drugs due to the dissolution of ZnO. Meanwhile, ZnO quantum dots not only rapidly dissolve in an acidic condition of cancer cells but also enhance the anti-cancer effect of Zn2+. An in vitro controlled release proliferation indicated that the acid sensitive ZnO gatekeepers showed well response by the ‘on-off’ switch of the pores. Cellular experiments against cervical cancer cell (HeLa cells) further showed that functionalized MMSN significantly suppressed cancer cells growth through synergistic effects between the chemotherapy and Zn2+ ions with monitoring the treatment process. These results suggested that the ZnO-gated MMSN platform is a promising approach to serve as a pH-sensitive system for chemotherapies delivery and Zn2+ controlled release for further application in the treatment of various cancers by synergistic effects.

【 授权许可】

CC BY