Rationale and protocol of the ENGAGE study: a double-blind randomized controlled preference trial using a comprehensive cohort design to measure the effect of a cognitive and leisure-based intervention in older adults with a memory complaint

Trials

N. D. Anderson¹  R. Jokel¹  G. Naglie¹  K. J. Murphy¹  A. K. Troyer¹  E. Rochon²  K. McGilton²  A. I. Ansaldo³  S. Belleville³  L. Bherer³  N. Bier³  M.-A. Bruneau³  A. Moussard³  L. L. Cuddy⁴  V. D. Bohbot⁵  K. Mahalingam⁶  B. Gilbert⁷  P. Belchior⁸ 

[1] 0000 0001 2157 2938, grid.17063.33, University of Toronto, Toronto, Canada;Baycrest Health Sciences, Toronto, Canada;0000 0001 2157 2938, grid.17063.33, University of Toronto, Toronto, Canada;Toronto Rehabilitation Institute - the University Health Network, Toronto, Canada;0000 0001 2292 3357, grid.14848.31, Université de Montréal, Montreal, Canada;grid.294071.9, Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, Canada;0000 0004 1936 8331, grid.410356.5, Queen’s University, Kingston, Canada;0000 0004 1936 8649, grid.14709.3b, McGill University, Montreal, Canada;0000 0001 2353 5268, grid.412078.8, Douglas Mental Health University Institute, Montreal, Canada;Baycrest Health Sciences, Toronto, Canada;grid.294071.9, Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, Canada;grid.294071.9, Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, Canada;0000 0004 1936 8649, grid.14709.3b, McGill University, Montreal, Canada;

关键词: Cognitive training;    Cognitive intervention;    Stimulating leisure activities;    Cognitive reserve;    Design;    Preference trial;    Dementia prevention;    Subjective cognitive decline;    Early mild cognitive impairment;   

DOI  :  10.1186/s13063-019-3250-6

来源: publisher

【 摘 要 】

BackgroundLeisure activities can be both enjoyable and cognitively stimulating, and participation in such activities has been associated with reduced age-related cognitive decline. Thus, integrating stimulating leisure activities in cognitive training programs may represent a powerful and innovative approach to promote cognition in older adults at risk of dementia. The ENGAGE study is a randomized controlled, double-blind preference trial with a comprehensive cohort design that will test the efficacy and long-term impact of an intervention that combines cognitive training and cognitively stimulating leisure activities.MethodsOne hundred and forty-four older adults with a memory complaint will be recruited in Montreal and Toronto. A particular effort will be made to reach persons with low cognitive reserve. Participants will be randomly assigned to one of two conditions: cognitive + leisure training (ENGAGE-MUSIC/SPANISH) or active control (ENGAGE-DISCOVERY). The ENGAGE-MUSIC/SPANISH training will include teaching of mnemonic and attentional control strategies, casual videogames selected to train attention, and classes in music or Spanish as a second language. The ENGAGE-DISCOVERY condition will comprise psychoeducation on cognition and the brain, low-stimulating casual videogames and documentary viewing with discussions. To retain the leisure aspect of the activities, participants will be allowed to exclude either music or Spanish at study entry if they strongly dislike one of these activities. Participants randomized to ENGAGE-MUSIC/SPANISH who did not exclude any activity will be assigned to music or Spanish based on a second random assignment. Training will be provided in 24 2-h sessions over 4 months. Outcomes will be measured at baseline, at 4-month follow-up, and at 24-month follow-up. The primary outcome will be cognitive performance on a composite measure of episodic memory (delayed recall scores for words and face-name associations) measured at baseline and at the 4-month follow-up. Secondary outcomes will include a composite measure of attention (speed of processing, inhibition, dual tasking, and shifting), psychological health, activities of daily living, and brain structure and function and long-term maintenance measured at the 24-month follow-up. Information on cognitive reserve proxies (education and lifestyle questionnaires), sex and genotype (apolipoprotein (Apo)E4, brain-derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT)) will be collected and considered as moderators of training efficacy.DiscussionThis study will test whether a program combining cognitive training with stimulating leisure activities can increase cognition and reduce cognitive decline in persons at risk of dementia.Trial registrationNCT03271190. Registered on 5 September 2017.

【 授权许可】

CC BY