An overview of carbonic anhydrases and membrane channels of synoviocytes in inflamed joints

Journal of Enzyme Inhibition and Medicinal Chemistry

Min Jeong Ji¹  Jeong Hee Hong¹ 

[1] Department of Physiology, College of Medicine, Gachon University, Lee Gil Ya Cancer and Diabetes Institute, Incheon, South Kore;

关键词: Synoviocytes;    migration;    carbonic anhydrases;    aquaporins;    ion channels;   

DOI  :  10.1080/14756366.2019.1659791

来源: publisher

【 摘 要 】

The highly aggressive fibroblast-like synoviocytes (FLSs) are inflammatory mediators involved in synovial joint destruction. Membrane channels and transporters are essential components of the cell migration apparatus and are involved in various cellular functions. Although evidence is emerging that cell migration is a physiological/pathological process, the mechanism of highly dynamic synoviocytes linked to the membrane channels and carbonic anhydrases (CAs) in inflamed joints is only partially understood. In this review, topics covered will give a brief overview of CAs and the membrane channels of synoviocytes. We have also systematically focused on the role of FLS channels and transporters under various conditions, including rheumatoid arthritis (RA), to understand the pathophysiology of the migration of synoviocytes as inflammatory mediators in joints.

【 授权许可】

CC BY